When cultured in GM3, NRP-152 cells undergo increased cell death/growth arrest by rapamycin (Fig. Transforming growth factor (TGF-) signaling antagonists similarly activated the Surivin promoter and rendered cells refractory to further promoter activation by IGF-I. IGF-I suppressed Arctigenin levels of phospho-Smads 2 and 3 with kinetics comparable to that of Survivin induction. Suppression of TGF- … Continue reading When cultured in GM3, NRP-152 cells undergo increased cell death/growth arrest by rapamycin (Fig